Why the study?
Does the dosing interval of misoprostol affect its efficacy in preventing aspirin-induced gastric injury in dogs?
Population
24 random-source dogs
Comparison
Misoprostol 3 microg/kg PO q8h, q12h, or q24h… vs Placebo PO q8h co-administered with aspirin 25…
Design
Preclinical
Follow-up
28 days
Authors
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May support q12h dosing in canine NSAID models; leaves open translation to clinical veterinary practice.
Does the dosing interval of misoprostol affect its efficacy in preventing aspirin-induced gastric injury in dogs?
In a canine model, twice-daily misoprostol is at least as effective as three-times-daily dosing for preventing aspirin-induced gastric injury.
Ward et al. (2003) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: