Production of Renin, Angiotensin II, and Aldosterone by Adrenal Explant Cultures: Response to Potassium and Converting Enzyme Inhibition*

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Population

Rat adrenal capsular/zona glomerulosa explants in a serum-free culture system

Design

Preclinical

Authors

Discussion

No immediate clinical implications from rat explants; leaves open local RAAS relevance in human adrenals.

Population

Rat adrenal capsular/zona glomerulosa explants in a serum-free culture system

Intervention

Potassium (6 mM) or the angiotensin converting enzyme inhibitor lisinopril (0.1 mM) added to the culture medium

Outcome

Production of aldosterone, angiotensin II, and proreninsurrogate

Rat adrenal explants possess a functional local renin-angiotensin-aldosterone system that responds to physiological stimuli and ACE inhibition.

Shier et al. (1989) studied this question.

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