Comparative Study of Hydrophilic Polymer-Based Solid Dispersions of Griseofulvin Incorporating HPMC E6, PVP K30, and Soluplus

Solid dispersion approach with hydrophilic carriers is one of the most effective methods for improving the solubility, dissolution profile, and ultimately the oral bioavailability of poorly water-soluble drugs. In this study, Griseofulvin (GF), a BCS class II drug with poor solubility and a strong tendency to recrystallize, was formulated using hydrophilic polymers (HPMC E6, Polyvinylpyrrolidone K30 (PVP), and Soluplus) at drug to polymer ratios of 1:2, 1:3, and 1:4 using the solvent evaporation method. An experimental polymer-selection approach was employed to determine the optimal carrier type and ratio, wherein drug–polymer compatibility studies (FTIR), solid-state characterization (PXRD), saturated solubility studies, and dissolution behavior were systematically evaluated. The 1:3 HPMC formula demonstrated the most favorable performance, showing superior saturated solubility, enhanced dissolution rate, and good stability at harsh conditions across 90 days. This formulation represents a promising approach for improving the biopharmaceutical properties of Griseofulvin.