Why the study?
Do chimpanzee monoclonal antibodies HEV#4 and HEV#31 neutralize the SAR-55 strain of Hepatitis E virus in rhesus monkeys?
Population
Rhesus monkeys (Macaca mulatta) and in vitro models (phage display from chimpanzee cDNA library)
Comparison
Chimpanzee monoclonal antibodies HEV#4 and HEV#31 vs Control animals receiving HEV inoculum without…
Design
Preclinical
Authors
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May inform HEV passive immunization strategies; leaves open translation from primate models to human use.
Do chimpanzee monoclonal antibodies HEV#4 and HEV#31 neutralize the SAR-55 strain of Hepatitis E virus in rhesus monkeys?
Two chimpanzee monoclonal antibodies, HEV#4 and HEV#31, successfully neutralized the SAR-55 strain of Hepatitis E virus in a rhesus monkey model.
Schofield et al. (2000) studied this question.
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