Why the study?
Hepatitis E virus is a frequent cause of acute hepatitis worldwide, yet knowledge of the virus and its life cycle remains scarce.
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Design
Overview
Should not yet change HEV clinical practice; leaves open replicon utility for therapeutic development.
Hepatitis E virus (HEV) has received relatively little attention for decades although it is now considered as one of the most frequent causes of acute hepatitis worldwide. Our knowledge of this enterically-transmitted, positive-strand RNA virus and its life cycle remains scarce but research on HEV has gained momentum more recently. Indeed, advances in the molecular virology of hepatitis E, including the establishment of subgenomic replicons and infectious molecular clones, now allow study of the entire viral life cycle and to explore host factors required for productive infection. Here, we provide an overview on currently available systems, with an emphasis on selectable replicons and recombinant reporter genomes. Furthermore, we discuss the challenges in developing new systems which should enable to further investigate this widely distributed and important pathogen.
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Oechslin et al. (2023) studied this question.
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