Population
Hepatitis E virus (HEV) capsid protein constructs (P2 domain)
Comparison
Dimerization vs Monomeric P2 domain constructs
Design
Preclinical
Authors
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May aid HEV gut survival; leaves open whether this informs human vaccines or antivirals.
Dimerization of the HEV capsid protein P2 domain protects it from trypsin digestion, suggesting an evolutionary mechanism for orally-transmitted viruses to survive the gastrointestinal environment.
Wei et al. (2018) studied this question.
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