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November 30, 2018HematologyOpen Access

Drug-drug interactions in an era of multiple anticoagulants: a focus on clinically relevant drug interactions

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Why the study?

Oral anticoagulants are commonly prescribed but carry a high risk of adverse events, making skilled drug interaction management essential for safe and effective therapy.

What are the clinically relevant drug-drug interactions with oral anticoagulants?

Population

Patients taking oral anticoagulants

Design

Review

Authors

SVSara R. VazquezUniversity of Utah

Discussion

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Implication

Supports routine interaction screening with oral anticoagulants; leaves open prospective validation of bleeding risks in real-world use.

Structured PICO

What are the clinically relevant drug-drug interactions with oral anticoagulants?

P
Population
Patients taking oral anticoagulants
I
Intervention
Concomitant use of interacting drugs (modifiers of cytochrome 2C9, 3A4, p-glycoprotein, antiplatelet agents, nonsteroidal anti-inflammatory drugs, and serotonergic agents)
O
Outcome
Adverse events (bleeding)safety

Skilled management of drug-drug interactions, including regular use of interaction databases, is essential to prevent adverse events in patients taking oral anticoagulants.

Cite This Study

Sara R. Vazquez (2018) studied this question.

synapsesocial.com/papers/6a8802e08c7e900eb714b84ehttps://doi.org/10.1182/asheducation-2018.1.339

Topics

Dual antiplatelet therapyAnticoagulation in AF
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