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November 1, 2025The Journal of ArthroplastyOpen Access

PhysiotherApeutic Treat-To-Target Intervention After Total Hip and Knee Arthroplasty Does Not Improve Outcomes Compared to Usual Physical Therapy: The PATIO Study

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Authors

LGLichelle GrootLeiden University Medical CenterMGMaaike G. J. GademanLeiden UniversityWPW.F. PeterLeiden University Medical Center

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Implication

Randomized trial finds treat-to-target physical therapy does not improve functional outcomes over usual care after hip or knee arthroplasty, suggesting standard rehabilitation remains sufficient.

Key Points

  • To evaluate whether a personalized, treat-to-target postoperative physical therapy strategy improves functional recovery compared to usual care following primary total hip or knee arthroplasty.
  • Conducted a nationwide cluster randomized superiority trial across 18 hospitals enrolling 624 patients (312 undergoing primary THA and 312 undergoing primary TKA).
  • Hospitals were randomized to implement either a personalized treat-to-target physical therapy strategy or standard postoperative physical therapy.
  • Physical functioning was measured preoperatively and at 6, 12, 24, and 52 weeks, with the primary endpoint analyzed at 3 months using HOOS-PS and KOOS-PS marginal models.
  • In the THA cohort, the 3-month change in HOOS-PS score was 19.9 (95% CI: 17.8 to 22.1) in the treat-to-target group versus 18.2 (95% CI: 16.0 to 20.5) in the usual care group, with no statistically significant difference.
  • In the TKA cohort, the 3-month change in KOOS-PS score was 31.3 (95% CI: 29.3 to 33.4) in the treat-to-target group versus 31.1 (95% CI: 29.0 to 33.2) in the usual care group, showing no statistically significant between-group difference.

Cite This Study

Groot et al. (2025) studied this question.

synapsesocial.com/papers/6a880814eb5451a844aa69f7https://doi.org/10.1016/j.arth.2025.10.049
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Performance milestones in postoperative physical therapy after total hip arthroplasty: impact on length of stay and discharge destination2018 · 5 citations
  2. 2Rationale and design of the PaTIO study: PhysiotherApeutic Treat-to-target Intervention after Orthopaedic surgery2020 · 4 citations
  3. 3Satisfactory adherence to the Dutch physical therapy guideline for patients with a total knee arthroplasty. A survey study involving 103 specialised physical therapists2024 · 1 citations
  4. 4Using the 0-to-10 Pain Rating Scale2001 · 48 citations
  5. 5The Impact of Physical Therapy Residency or Fellowship Education on Clinical Outcomes for Patients With Musculoskeletal Conditions2015 · 85 citations