Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 23, 2016Journal of Alzheimer s Disease

Cortical Amyloid Burden Differences Across Empirically-Derived Mild Cognitive Impairment Subtypes and Interaction with APOE ɛ4 Genotype

View Full Paper
Ask AI
Bookmark
Share

Population

583 ADNI participants with baseline florbetapir positron emission tomography amyloid imaging and…

Design

Cross-sectional

Authors

KBKatherine J. BangenACAlexandra L. ClarkMWMadeline Werhane

Discussion

Loading...

Member takes

Overview

May indicate false-positive MCI diagnoses from amyloid heterogeneity; leaves open validation of subtype-specific criteria in prospective studies.

Structured PICO

P
Population
583 ADNI participants (444 with mild cognitive impairment [MCI], 139 normal controls) with baseline florbetapir positron emission tomography (PET) amyloid imaging and neuropsychological testing.
O
Outcome
Cortical amyloid-β (Aβ) levels and interactions with apolipoprotein (APOE) ɛ4 genotype statussurrogate

Considerable heterogeneity exists in amyloid-beta levels across empirically-derived MCI subtypes, suggesting conventional MCI criteria may be susceptible to false positive diagnostic errors.

Cite This Study

Bangen et al. (2016) studied this question.

synapsesocial.com/papers/6a880816afcf99b77fbbf405https://doi.org/10.3233/jad-150900
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease2014 · 226 citations
  2. 2Alzheimer’s disease drug-development pipeline: few candidates, frequent failures2014 · 1,787 citations
  3. 3Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions2005 · 542 citations
  4. 4The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease2011 · 19,146 citations
  5. 5Functional and cognitive criteria produce different rates of mild cognitive impairment and conversion to dementia2009 · 107 citations