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Proposed homologies in actin-binding sites remain hypothesis-generating; leaves open experimental validation of shared structural features.
We review the impact of molecular biology on actin binding proteins, in particular on sequence relationships and expression of clones to dissect properties in vitro. Significant homologies exist between proteins in each class, but we propose, in addition, that common structural features exist between the F-actin binding sites of severing and cross-linking proteins.
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Way et al. (1991) studied this question.
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