Population
Actin crosslinking proteins (spectrin, alpha-actinin, ABP-120, ABP-280, fimbrin, and dystrophin)
Design
Other
Authors
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May inform dystrophin variant interpretation in cardiomyopathy; leaves open functional roles in cardiac cytoskeletal disease.
Actin crosslinking proteins share a homologous actin-binding domain but differ in structure due to evolutionary shuffling and multiplication of other sequence segments.
Ronald R. Dubreuil (1991) studied this question.
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