Biflavonoid Anti-inflammatory Activity of the Araucariaceae Family—A Review

The Araucariaceae family, a group of coniferous plants, has gained attention for its diverse bioactive compounds, particularly biflavonoids. These natural polyphenolic compounds have demonstrated significant anti-inflammatory properties, making them a promising target for pharmacological research. This review consolidates and critically analyzes the current knowledge on the anti-inflammatory activity of biflavonoids isolated from the Araucariaceae family. It explores their chemical structures, mechanisms of action, and potential therapeutic applications. Special attention is given to their ability to modulate key inflammatory pathways, including cytokine suppression, NF-κB inhibition, and antioxidant activity. Additionally, the review highlights challenges in harnessing these compounds for drug development, such as bioavailability and scalability, and discusses future directions in modern drug discovery. By providing a comprehensive overview, this study aims to bridge gaps in the literature and underscore the potential of Araucariaceae-derived biflavonoids in addressing inflammation-related diseases.