February 1, 1993Endocrinology

Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature.

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Population

Cultured rat vascular smooth muscle cells (VSMC) and bovine endothelial cells (EC)

Comparison

Endothelin-1, Endothelin-3, ETA receptor… vs null

Design

Preclinical

Authors

SESatoru EguchiVascular Medicine YHY HirataKasugai Municipal Hospital TIT ImaiOgaki Municipal Hospital

Discussion

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Implication

Differential ET receptor G-protein coupling in animal vasculature extends mechanistic insights; leaves open human relevance.

Structured PICO

Population

Cultured rat vascular smooth muscle cells (VSMC) and bovine endothelial cells (EC)

Intervention

Endothelin-1 (ET-1), Endothelin-3 (ET-3), ETA receptor antagonist (BQ-123), ETB receptor agonist (BQ-3020), cholera toxin, pertussis toxin, isoproterenol, forskolin, indomethacin, quinacrine

Comparator

null

Outcome

cAMP formation (adenylate cyclase activity)surrogate

ETA and ETB receptor subtypes are functionally coupled to adenylate cyclase via Gs in vascular smooth muscle cells and Gi in endothelial cells, respectively.

Cite This Study

Eguchi et al. (1993) studied this question.

synapsesocial.com/papers/6a880c98aaaef52b1e4decf4 https://doi.org/10.1210/endo.132.2.7678793

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Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider