Why the study?
Do baseline viral load and CD8 cell count influence the increase in CD4 T-cell count in patients initiating tritherapy with protease inhibitors?
Do baseline viral load and CD8 cell count influence the increase in CD4 T-cell count in patients initiating tritherapy with protease inhibitors?
Patients with lower baseline viral loads experience smaller increases in CD4 T-cell counts when initiating protease inhibitor-based tritherapy, suggesting alternative mechanisms of CD4 destruction.
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Baseline markers may stratify early CD4 recovery risk on PI regimens; hypothesis-generating for alternative CD4 loss mechanisms and needs prospective validation.
Keïta-Perse et al. (1998) studied this question.
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