November 1, 1978Journal of Biological ChemistryOpen Access

Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides

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Population

Soluble splenic cell guanylate cyclase enzyme preparation

Comparison

Prostaglandin endoperoxides and fatty acid… vs Baseline activity and other fatty acids

Design

Preclinical

Authors

GGG. GraffPurdue University West Lafayette JSJ.H. StephensonUniversity of Minnesota Medical Center DGDavid B. GlassUniversity of Southern California

Discussion

Member takes

Implication

May link lipid peroxides to cGMP pathways; leaves open cardiovascular relevance or therapeutic translation in humans.

Structured PICO

Population

Soluble splenic cell guanylate cyclase enzyme preparation

Intervention

Prostaglandin endoperoxides (PGG2 and PGH2) and fatty acid hydroperoxides (12-OOH-20:4, 15-00H-20:4, and 13-OOH-18:2)

Comparator

Baseline activity and other fatty acids (PGE2, PGF2a, hydroxy fatty acids, saturated and unsaturated fatty acids)

Outcome

Guanylate cyclase activitysurrogate

Prostaglandin endoperoxides and fatty acid hydroperoxides activate soluble splenic cell guanylate cyclase by oxidizing enzyme-related thiol functions.

Cite This Study

Graff et al. (1978) studied this question.

synapsesocial.com/papers/6a880d0db0d802598bf4d227 https://doi.org/10.1016/s0021-9258(17)34422-8

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Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider