Bradycardia Induced by Interaction Between Quinidine and Ophthalmic Timolol

Brief Reports1 December 1985Bradycardia Induced by Interaction Between Quinidine and Ophthalmic TimololYAEL DINAI, M.D., MORDECHAI SHARIR, M.D., NAVA NAVEH (FLOMAN), M.D., HILLEL HALKIN, M.D.YAEL DINAI, M.D.Search for more papers by this author, MORDECHAI SHARIR, M.D.Search for more papers by this author, NAVA NAVEH (FLOMAN), M.D.Search for more papers by this author, HILLEL HALKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-890 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTopical administration of timolol, a beta-blocking agent, is currently the treatment of choice in open-angle glaucoma (1). This route of administration delivers the drug directly to the systemic circulation, whereas oral doses are subject to presystemic hepatic metabolism (2). Systemic complications, such as severe bradycardia, have been associated with ophthalmic timolol (3). No adverse interaction has been reported, to our knowledge, with the coadministration of ocular timolol and oral quinidine. We report a case of sinus bradycardia related to an interaction between ophthalmic timolol and oral quinidine, substantiated by the negative rechallenge with timolol alone and by positive rechallenge with...References1. KOCH-WESERFRISHMAN JW. Beta-adrenoreceptor antagonists: new drugs and new indications. N Engl J Med. 1981;305:500-6. CrossrefMedlineGoogle Scholar2. ALVANCALISSENDORFSEIDEMANWIDMARDWIDMARD GBPKG. Absorption of ocular timolol. Clin Pharmacokinet. 1980;5:95-100. CrossrefMedlineGoogle Scholar3. MCMAHONSHAFFERHOSKINSHETHERINGTON CRHJ. Adverse effects experienced by patients taking timolol. Am J Ophthalmol. 1979;88:736-8. CrossrefMedlineGoogle Scholar4. DAVIDSONRIBAKECKSTEINBARISHAK JJDR. Timolol maleate: side effects on healthy nonglaucomatous volunteers. Aviat Space Environ Med. 1983;54;360-2. MedlineGoogle Scholar5. ROSDAKE FC. Timolol eye drops: bradycardia or tachycardia? Doc Ophthalmol. 1979;48:283-9. CrossrefGoogle Scholar6. MASONWINKLERIDERSTINSONHARRISON JRAED. The electrophysiologic effects of quinidine in the transplanted human heart. J Clin Invest. 1977;59:481-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: YAEL DINAI, M.D.; MORDECHAI SHARIR, M.D.; NAVA NAVEH (FLOMAN), M.D.; HILLEL HALKIN, M.D.Affiliations: Sheba Medical Center Tel Hashomer Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical Management of GlaucomaMedical Management of GlaucomaCardiac safety of ophthalmic timololQuinidineParoxetine Markedly Increases Plasma Concentrations of Ophthalmic Timolol; CYP2D6 Inhibitors May Increase the Risk of Cardiovascular Adverse Effects of 0.5% Timolol Eye DropsMetabolism of Ophthalmic Timolol: New Aspects of an Old DrugGlaucoma and Systemic DiseasesANTIDYSRHYTHMIC DRUGSMedical Management of GlaucomaQuinidineSymptomatic bradycardia secondary to interaction between topical timolol maleate, verapamil, and flecainide: a case reportCARDIOVASCULAR DRUG-DRUG INTERACTIONSOphthalmically Administered ? Blockers and Their Cardiopulmonary EffectsMedical Management of GlaucomaChronic open-angle glaucoma and lifestyleSympatholytikaThe Clinical Significance of the Pharmacogenetics of Cardiovascular MedicationsQuinidine: Is it a good drug or a bad drug?Eye DisordersSystemic drug interactions with topical glaucoma medicationsOphthalmic Topical Beta Blockers: Review of Ocular and Systemic Adverse EffectsTimolol metabolism and debrisoquine oxidation polymorphism: a population study.Accidents systémiques des bêta-bloquants en collyresCardiac glycosides and drugs used in dysrhythmias 1 December 1985Volume 103, Issue 6_Part_1Page: 890-891KeywordsBradycardiaClinical pharmacologyDrug metabolismDrugsGlaucomaOral administrationRoutes of administration ePublished: 1 December 2008 Issue Published: 1 December 1985 Copyright & Permissions©1985 American College of PhysiciansPDF downloadLoading ...