Why the study?
Does quinidine alter electrophysiologic parameters directly or via autonomic mediation in cardiac transplant recipients?
Population
5 cardiac transplant recipients with anatomically denervated hearts
Comparison
Quinidine gluconate 10 mg/kg infused over 20… vs Baseline control conduction interval and…
Design
Case_series
Follow-up
30 minutes
Authors
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Suggests direct quinidine effects on atrial/His-Purkinje tissue in transplants; leaves open confirmation of autonomic mediation in larger cohorts.
Does quinidine alter electrophysiologic parameters directly or via autonomic mediation in cardiac transplant recipients?
Quinidine exerts direct effects on atrial refractoriness and His-Purkinje conduction, while its sinus and AV nodal effects are autonomically mediated.
Mason et al. (1977) studied this question.
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