Why the study?
Does the addition of intravenous verapamil to quinidine counteract quinidine-induced rapid AV conduction in patients?
Population
8 patients during sinus rhythm and atrial stimulation
Comparison
320 mg quinidine administered intravenously… vs Quinidine alone (sequential administration design)
Design
Case_series
Authors
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May support combined quinidine-verapamil use for rate control in atrial arrhythmias; hypothesis-generating case report requiring prospective validation.
Does the addition of intravenous verapamil to quinidine counteract quinidine-induced rapid AV conduction in patients?
Verapamil counteracts the quinidine-induced acceleration of AV nodal conduction, providing an electrophysiological rationale for their combined use to prevent rapid ventricular rates during atrial arrhythmias.
Theisen et al. (1983) studied this question.
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