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March 1, 1977HeartOpen Access

Clinical and electrophysiological effects of intravenous quinidine in man.

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Why the study?

What are the clinical and electrophysiological effects of intravenous quinidine in patients with arrhythmias, including those with bundle-branch block?

Population

20 patients with either frequent premature ventricular contractions or supraventricular arrhythmias, 16 of…

Design

Case_series

Follow-up

during and immediately after 22-minute infusion

Authors

DHDavid S. HirschfeldSan Francisco General HospitalCUC T UedaSan Francisco General HospitalMRMarion RowlandNewcastle University

Discussion

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Implication

May warrant hypotension monitoring with IV quinidine; leaves open conduction safety in larger bundle-branch block cohorts.

Structured PICO

What are the clinical and electrophysiological effects of intravenous quinidine in patients with arrhythmias, including those with bundle-branch block?

P
Population
20 patients with either frequent premature ventricular contractions or supraventricular arrhythmias, 16 of whom had bundle-branch block.
I
Intervention
Intravenous quinidine gluconate (total dose 4.4 to 9.1 mg/kg, or 0.3 to 0.4 mg/kg per min) infused over 22 minutes.
O
Outcome
Electrophysiological effects (heart rate, atrioventricular nodal, and infranodal conduction times, QRS duration) and clinical effects (hypotension, toxicity).surrogate

Intravenous quinidine can be administered to patients with bundle-branch block without significant conduction worsening, though it frequently causes hypotension requiring careful monitoring.

Cite This Study

Hirschfeld et al. (1977) studied this question.

synapsesocial.com/papers/6a6ff88da528af2d65c3417ehttps://doi.org/10.1136/hrt.39.3.309
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interactions of Quinidine and Potassium on Atrioventricular Transmission1967 · 47 citations
  2. 2THE MODE OF ACTION OF QUINIDINE ON ISOLATED RABBIT ATRIA INTERPRETED FROM INTRACELLULAR POTENTIAL RECORDS1958 · 124 citations
  3. 3A Possible Mechanism of Action of Quinidine1957 · 60 citations
  4. 4Study of Atrioventricular Conduction in Man Using Electrode Catheter Recordings of His Bundle Activity1969 · 172 citations
  5. 5His Bundle Recordings in Patients with Bundle Branch Block and Transient Neurologic Symptoms1973 · 64 citations