Why the study?
Is the platelet larger cell ratio (P-LCR) elevated in patients with dyslipidemia compared to normal controls?
Is the platelet larger cell ratio (P-LCR) elevated in patients with dyslipidemia compared to normal controls?
P-LCR is significantly elevated in patients with dyslipidemia, suggesting it may serve as a risk indicator for thromboembolic ischemic events.
Elevated P-LCR in dyslipidemia may signal thromboembolic risk; hypothesis-generating and requires prospective validation before clinical use.
We have described preliminary results of platelet larger cell ratio (P-LCR) analysis, provided by an automated hematology analyzer in patients with hypercholesterolemia and/or hypertriglyceremia. P-LCR values were significantly higher in patients (n = 41) than in control normal group (n = 20) (P < 0.0001). Larger platelets are more reactive and contribute to vasooclusive events in patients with dyslipidemia. P-LCR may be used as an indicator of risk factor for thromboembolic ischemic events.
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Grotto et al. (2004) studied this question.
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