January 1, 1999Acta Haematologica
Influence of Aspirin on Platelet Count and Volume in Humans
Why the study?
Does aspirin 250 mg daily affect platelet count, volume, and total platelet mass in healthy young male volunteers?
Population
20 healthy young male volunteers
Comparison
Aspirin 250 mg daily for 7 days vs Placebo
Design
RCT, randomized, double-blind
Follow-up
7 days
Authors
Discussion
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Implication
Potential confounding of serial platelet counts in aspirin users with frequent sampling; extends RCT data on hematologic effects in healthy volunteers.
Structured PICO
Does aspirin 250 mg daily affect platelet count, volume, and total platelet mass in healthy young male volunteers?
P
Population
20 healthy young male volunteers
I
Intervention
Aspirin 250 mg daily for 7 days
C
Comparator
Placebo
O
Outcome
Platelet count, volume, and total platelet masssurrogate
Aspirin treatment combined with repeated blood sampling increases platelet count and total platelet mass in healthy volunteers.
Cite This Study
Erhart et al. (1999) studied this question.