Surface patterns of wavebreak during sustained ventricular fibrillation in swine right ventricles are produced by head-to-tail interaction between waves and filament break.
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Wavebreak mechanisms clarified in swine VF models; leaves open translation to human arrhythmia substrates.
Background竊숾everal different patterns of wavebreak have been described by mapping of the tissue surface fibrillation. However, it is not clear whether these surface patterns are caused by multiple distinct mechanisms by a single mechanism. Method竊숿o determine the mechanism by which wavebreaks are gener-ated ventricular fibrillation, we conducted optical mapping studies and single cell transmembrane potential in 6 isolated swine right ventricles. Results竊숤mong 763 episodes of wavebreak (0.75 times/sec/cm2), maps showed 3 patterns竊�80% due to a wavefront encountering the refractory waveback of another, 11.5% due to wavefronts passing perpendicularly each other and 8.5% due to a new (target) wave arising beyond the refractory tail of a previous wave. Computer simulations of scroll waves in 3-D tissue showed these surface patterns could be attributed to two fundamental mechanisms竊쉎ead-to-tail interactions and break. Conclusion竊쉂e conclude that during sustained ventricular fibrillation in swine RV, surface of wavebreak are produced by two fundamental mechanisms竊쉎ead-to-tail interaction between waves filament break. (Korean Circulation J 2000;30(11):1404-1416)
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Lee et al. (2000) studied this question.
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