June 25, 1993Science

Evidence of Genetic Heterogeneity in the Long QT Syndrome

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Why the study?

Is there evidence of genetic heterogeneity in familial long QT syndrome?

Population

131 individuals from a large Jewish family with a history of long QT syndrome, of whom 28 are affected.

Design

Cohort

Follow-up

over 7 years

Authors

Discussion

Supports broader genetic evaluation in LQTS families; leaves open precise additional loci for clinical translation.

Is there evidence of genetic heterogeneity in familial long QT syndrome?

Population

131 individuals from a large Jewish family (originating from Jerba, residing in Israel) with a history of long QT syndrome, of whom 28 are affected.

Intervention

Genetic linkage analysis

Outcome

Evidence of genetic heterogeneity in the determination of long QT syndromesurrogate

This study demonstrates genetic heterogeneity in long QT syndrome, indicating that mutations at loci other than H-ras-1 can cause the disease.

Benhorin et al. (1993) studied this question.

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