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February 28, 2014BloodOpen Access

A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding

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Authors

LSLucia StefaniniSapienza University of RomeFYFeng YeUniversity of AlbertaASAdam K. Snider

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Stefanini et al. (2014) studied this question.

synapsesocial.com/papers/6a881145afcf99b77fbbf6e9https://doi.org/10.1182/blood-2013-12-543363
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain2001 · 223 citations
  2. 2The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy2010 · 78 citations
  3. 3CalDAG-GEFI is at the nexus of calcium-dependent platelet activation2009 · 153 citations
  4. 4The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion2000 · 416 citations