Why the study?
Whether an association exists between HF and cancer has not been conclusively established, and it is unclear if cancer patients share similar hospitalization strategies and outcomes with HF patients.
Is genetic predisposition to heart failure associated with the risk of developing various cancers?
Is genetic predisposition to heart failure associated with the risk of developing various cancers?
Mendelian randomization suggests a trend toward a negative causal relationship between heart failure and the occurrence of several types of cancer, identifying ABO and SURF1 as key shared genetic factors.
May link HF genetic risk to lower incidence of several cancers; hypothesis-generating and requires validation before any clinical inference.
Background: Whether there is an association between HF (HF) and cancer has not been conclusively established, and it is not clear whether patients with cancer can share similar hospitalization strategies and outcomes with patients with HF. Methods: Genome-wide association summary statistics were performed using a two-sample Mendelian randomization (MR) method for HF patients and cancer patients from the GWAS directory, with co-localization and Summary Data-Based Mendelian Randomization (SMR) analyses to identify HF-associated genes, and transcriptomic analyses to analyze the roles of these genes in the clinical diagnosis and targeted therapies of multiple cancer types. Results: Two-sample MR analysis showed that increased risk of HF was associated with decreased risk of cervical, brain, breast, colorectal, lung, and skin cancers, and co-localization combined with SMR analysis identified ABO and SURF1 as HF-associated genes, and transcriptomic analyses showed that ABO is a risk factor for HF and a protective factor against cancer, whereas SURF1 is a protective factor against HF and a protective factor against cancer. Conclusion: There was no causal relationship between heart failure and cancers (Cervical, brain, breast, colorectal, lung and skin cancers) risk factors, however there was a trend toward a negative causal relationship between heart failure and cancers (Cervical, brain, breast, colorectal, lung and skin cancers) occurrence.
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Sun et al. (2024) studied this question.
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