October 25, 2014BloodOpen Access

Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice

View Full Paper

Ask AI

Bookmark

Population

Mice in a 10% FeCl3-induced arterial thrombosis model (including Tsp1/Vwf, Vwf, Tsp1, wild-type, Tsp1/Vwf…

Comparison

Genetic deficiency of Thrombospondin 1 and/or… vs Wild-type mice or respective control strains…

Design

Preclinical

Authors

PPPrem PrakashJamia Hamdard PKParesh P. KulkarniCleveland Clinic ACAnil K. ChauhanUniversity of Iowa

Discussion

Member takes

Implication

Supports TSP1 role in murine arterial thrombosis; leaves open human relevance and therapeutic targeting.

Structured PICO

Population

Mice in a 10% FeCl3-induced arterial thrombosis model (including Tsp1(-/-)/Vwf(-/-), Vwf(-/-), Tsp1(-/-), wild-type, Tsp1(-/-)/Vwf(+/-), and Vwf(+/-) strains)

Intervention

Genetic deficiency of Thrombospondin 1 (TSP1) and/or von Willebrand factor (VWF)

Comparator

Wild-type mice or respective control strains (e.g., Vwf(-/-) or Vwf(+/-))

Outcome

Platelet adhesion, rate of thrombus growth, and occlusion time measured via intravital microscopysurrogate

TSP1 released from platelets plays a mechanistic role in modulating arterial thrombosis, but this process requires the presence of von Willebrand factor.

Cite This Study

Prakash et al. (2014) studied this question.

synapsesocial.com/papers/6a88124e657a5e32d1aa6375 https://doi.org/10.1182/blood-2014-06-581942

View Full Paper

Ask AI

Bookmark

Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider