Nonsteroidal Anti-inflammatory Drugs-sparing Effect of Symptomatic Slow-acting Drugs for Osteoarthritis in Knee Osteoarthritis Patients

Soo‐Kyung Cho; Hyoungyoung Kim; Ha‐Rim Park; Wooseok Choi; Seongmi Choi; Sun‐Young Jung; Eun Jin Jang; Yoon‐Kyoung Sung

doi:10.4078/jrd.2019.26.3.179

January 1, 2019Journal of Rheumatic DiseasesOpen Access

Nonsteroidal Anti-inflammatory Drugs-sparing Effect of Symptomatic Slow-acting Drugs for Osteoarthritis in Knee Osteoarthritis Patients

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Key Points

To evaluate the nonsteroidal anti-inflammatory drug (NSAID)-sparing effect of symptomatic slow-acting drugs for osteoarthritis (SYSADOA) in patients with knee osteoarthritis.
Retrospective cohort study of knee osteoarthritis patients presenting as baseline NSAID users at a single academic referral hospital between 2013 and 2014 (n=212; mean follow-up 369.1 days).
Patients were categorized into SYSADOA users (n=57) and SYSADOA non-users (n=155) and followed until NSAID discontinuation, last visit, or July 2017.
Multivariable Cox regression analysis was performed to evaluate the time to NSAID discontinuation after adjusting for baseline confounders.
SYSADOA users presented with more severe baseline disease than non-users, including higher rates of Kellgren-Lawrence grade ≥3 (66.7% vs. 42.6%, p=0.02) and more frequent intra-articular injections (33.3% vs. 9.0%, p<0.01).
SYSADOA use significantly increased the likelihood of NSAID discontinuation compared to non-use (hazard ratio 2.97, 95% CI 1.42–6.22).

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Implication

Retrospective cohort study finds symptomatic slow-acting drugs accelerate NSAID discontinuation in knee osteoarthritis, indicating a clinically meaningful drug-sparing effect.

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Cho et al. (2019) studied this question.

synapsesocial.com/papers/6a8812a18c7e900eb714bd4e https://doi.org/10.4078/jrd.2019.26.3.179

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Nonsteroidal Anti-inflammatory Drugs-sparing Effect of Symptomatic Slow-acting Drugs for Osteoarthritis in Knee Osteoarthritis Patients

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Nonsteroidal Anti-inflammatory Drugs-sparing Effect of Symptomatic Slow-acting Drugs for Osteoarthritis in Knee Osteoarthritis Patients

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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