Abstract 5‐Fluorouracil (5‐FU) is a chemotherapeutic agent, which is administered systemically for the palliative treatment of certain neoplastic diseases. Because 5‐FU is a potent antimetabolite, it is recommended that the drug be given only by physicians experienced in the use of antimetabolites. Now that 5‐FU is being applied topically for the treatment of skin neoplasms, it would be useful to review the metabolism and pharmacology of this compound. In this paper, the metabolic pathways, the antineoplastic mechanism of action, and the effects on normal tissues are discussed.
No takes yet. Share an insight, caveat, or question.
Edward Miller (1971) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: