Key result
Increased expression of TLR-4 on CD14++CD16+ monocytes was independently associated with the presence of intracoronary vulnerable plaques in patients with stable angina pectoris (OR 1.123).
Why the study?
Is the expression of TLR-4 on circulating monocytes associated with coronary plaque vulnerability assessed by MDCT in patients with stable angina pectoris?
Cross-Sectional (n=65)
No
Is the expression of TLR-4 on circulating monocytes associated with coronary plaque vulnerability assessed by MDCT in patients with stable angina pectoris?
Odds Ratio: 1.123 (95% CI 1.016–1.241)
Absolute Event Rate: 10.4% vs 4.5%
p-value: p=0.023
Expression of TLR-4 on circulating monocytes may serve as a biomarker for coronary plaque vulnerability in patients with stable angina pectoris.
Monocyte TLR-4 expression may mark plaque vulnerability in stable angina; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: Although Toll-like receptor 4 (TLR-4) is involved in monocyte activation in patients with accelerated forms of atherosclerosis, the relationship between the expression of TLR-4 on circulating monocytes and coronary plaque vulnerability has not previously been evaluated. We investigated this relationship using 64-slice multidetector computed tomography (MDCT) in patients with stable angina pectoris (SAP). METHODS AND RESULTS: monocytes positively correlated with the remodeling index (r=0.28, P=0.025) and negatively correlated with CT attenuation value (r=-0.31, P=0.013). CONCLUSIONS: monocytes might be associated with coronary plaque vulnerability in patients with SAP.
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Ozaki et al. (2017) conducted a cross-sectional in Stable angina pectoris (n=65). TLR-4 expression on CD14++CD16+ monocytes vs. Lower TLR-4 expression was evaluated on Presence of intracoronary vulnerable plaque (OR 1.123, 95% CI 1.016-1.241, p=0.023). Increased expression of TLR-4 on CD14++CD16+ monocytes was independently associated with the presence of intracoronary vulnerable plaques in patients with stable angina pectoris (OR 1.123).
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