Key result
Non-diabetic subjects whose 2-h post-load plasma glucose did not return to fasting levels exhibited significantly higher carotid intima-media thickness, blood pressure, and lower insulin sensitivity.
Why the study?
Do subjects with normal glucose tolerance whose 2-h post-load plasma glucose does not return to fasting levels have a more atherogenic cardiovascular risk profile compared to those whose levels return to fasting?
Population
266 non-diabetic offspring of type 2 diabetic patients with normal glucose tolerance (NGT)
Comparison
Group II: NGT subjects whose plasma glucose… vs Group I: NGT subjects whose 2-h glucose returns…
Design
Cross-sectional
Authors
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Subjects with normal glucose tolerance whose plasma glucose does not return to fasting levels within 2 hours during an OGTT have a more atherogenic profile, suggesting higher cardiovascular risk.
Cross-Sectional (n=266)
Do subjects with normal glucose tolerance whose 2-h post-load plasma glucose does not return to fasting levels have a more atherogenic cardiovascular risk profile compared to those whose levels return to fasting?
Subjects with normal glucose tolerance whose plasma glucose does not return to fasting levels within 2 hours during an OGTT have a more atherogenic profile, suggesting higher cardiovascular risk.
Succurro et al. (2009) conducted a cross-sectional in Normal glucose tolerance (n=266). 2-h post-load plasma glucose not returning to fasting level vs. 2-h post-load plasma glucose returning to or dropping below fasting level was evaluated on Cardiovascular risk factors, carotid intima-media thickness (IMT), and insulin sensitivity. Non-diabetic subjects whose 2-h post-load plasma glucose did not return to fasting levels exhibited significantly higher carotid intima-media thickness, blood pressure, and lower insulin sensitivity.
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