Key result
Among adults without diabetes, a 1% increase in HbA1c was independently associated with a higher risk of advanced coronary artery calcification progression over 5 years (RR 1.78).
Why the study?
Is higher HbA1c associated with the progression of coronary artery calcification in adults without diabetes?
Population
2,076 participants without diabetes from the Coronary Artery Risk Development in Young Adults study, with…
Design
Cohort
Follow-up
5 years
Authors
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May signal elevated CAC progression risk in nondiabetic adults; leaves open whether glycemic intervention modifies outcomes.
Cohort (n=2,076)
Yes
Is higher HbA1c associated with the progression of coronary artery calcification in adults without diabetes?
Relative Risk: 1.78 (95% CI 1.08–2.95)
In adults without diabetes, higher HbA1c levels are independently associated with advanced progression of coronary artery calcification, suggesting a role in accelerated subclinical atherosclerosis.
Carson et al. (2014) conducted a cohort in Adults without diabetes (n=2,076). Hemoglobin A1c (HbA1c) vs. Lower HbA1c levels was evaluated on Advanced CAC progression (>100 Agatston units) per 1% increase in HbA1c (multivariable adjusted) (RR 1.78, 95% CI 1.08, 2.95). Among adults without diabetes, a 1% increase in HbA1c was independently associated with a higher risk of advanced coronary artery calcification progression over 5 years (RR 1.78).
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