Why the study?
Does prostaglandin F2alpha or indomethacin alter the expression and activity of MMP-2, MMP-9, and TIMP-1 in human term decidua and fetal membranes?
Does prostaglandin F2alpha or indomethacin alter the expression and activity of MMP-2, MMP-9, and TIMP-1 in human term decidua and fetal membranes?
PGF2alpha increases decidual gelatinolytic activity, while indomethacin reduces it in fetal membranes, which may explain its labour-arresting properties.
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PGF2α may promote and indomethacin inhibit membrane gelatinolysis; leaves open translation to human labor mechanisms or tocolysis.
Ulun Uluğ (2001) studied this question.
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