Key result
Good adherence to pharmacological treatment guidelines at discharge was associated with a significant reduction in 1-year mortality (adjusted HR 0.574) compared to poor adherence in patients with systolic heart failure.
Why the study?
Does good guideline adherence to pharmacological therapies improve clinical outcomes in patients with systolic heart failure?
Population
1,297 adults with systolic heart failure admitted to 23 university hospitals in Korea, median age 69, 56.3%…
Comparison
Good guideline adherence, defined as… vs Poor guideline adherence, defined as…
Design
Cohort
Follow-up
median 272 days (interquartile range, 65–366 days)
Authors
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Supports GDMT adherence at discharge in systolic HF; leaves open causal confirmation and practice change pending RCTs.
Observational (n=1,297)
Yes
Does good guideline adherence to pharmacological therapies improve clinical outcomes in patients with systolic heart failure?
Hazard Ratio: 0.574 (95% CI 0.347–0.951)
Absolute Event Rate: 5.3% vs 10.2%
p-value: p=0.031
In real-world Korean patients with systolic heart failure, good adherence to guideline-directed medical therapy at discharge is associated with significantly improved 1-year survival.
Yoo et al. (2014) conducted an observational in Systolic heart failure (n=1,297). Good guideline adherence (GAI ≥50%) vs. Poor guideline adherence (GAI <50%) was evaluated on 1-year mortality (HR 0.574, 95% CI 0.347-0.951, p=0.031). Good adherence to pharmacological treatment guidelines at discharge was associated with a significant reduction in 1-year mortality (adjusted HR 0.574) compared to poor adherence in patients with systolic heart failure.
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