Chronic Hereditary Edema: Milroy's Disease

The condition now under consideration was first designated by my name by Sir William Osler, in his work on the practice of medicine. The original account of the disease was published in 1892 under the title "An Undescribed Variety of Hereditary Oedema."¹Six years later Henry Meige, in France, published an account of similar cases. In France and other continental countries the condition is sometimes called "Meige's disease." My paper gave a definite account of twenty-two occurrences of this edema in six generations of a family consisting of ninety-seven persons. Not long ago it occurred to me that, thirty-five years having elapsed, a new generation of this family had been arriving and it would be interesting to learn whether the family peculiarity was still persisting. After a rather prolonged effort in a follow-up investigation, I found it impossible to secure complete and dependable data. However, I located thirty additional