Key result
Among 1,201 swine samples from China, the infection rates of PCV2 and PCV3 were 72.1% and 26.3%, respectively, with a coinfection rate of 18.6% and PCV2d as the dominant genotype.
Why the study?
The study was conducted to elucidate the prevalence, molecular evolution, and coinfection of PCV2 and PCV3 in China.
Cross-Sectional (n=1,201)
Yes
The study identifies the dominant epidemic genotypes and mutation sites of PCV2 and PCV3 in Chinese swine herds, aiding in diagnosis and control.
Answers are grounded in this paper and cite their sources.
Dominant PCV2d in Chinese swine warrants genotype-specific surveillance; extends prior surveys but leaves open intervention efficacy.
To elucidate the prevalence, molecular evolution, and coinfection of PCV2 and PCV3 in China, we collected samples from six large-scale swine herds located in Heilongjiang, Henan, Hebei, and Hubei provinces and Xinjiang Uygur autonomous region from 2020 to 2021. Overall, 1,201 samples were analyzed and sequenced by PCR to identify the dominant genotypes of PCV2 and PCV3, and genetic variations in the capsid protein genes of PCV2 and PCV3 were evaluated. The major epidemic genotypes of PCV2 and PCV3 were different across different regions. The infection rate of PCV2 and PCV3 was 72.1% and 26.3%, respectively, and the coinfection rate was 18.6%. PCV2d was the dominant genotype across all herds. The PCV2d-positive rate in PCV2-positive samples was 93.5%-100% in five out of six herds, indicative of its predominance. PCV3 prevalence in China widely varied, and no dominant genotype was identified. Four, 21, 11, and 11 strains with PCV2a, PCV2d, PCV3a, and PCV3c genotypes were detected, respectively, with the capsid protein containing four, five, eight, and three aa sites with mutations, respectively. Overall, our findings revealed the dominant epidemic genotypes of PCV2 and PCV3 in six herds across five provinces in China, in addition to the main aa sites with mutations in the capsid protein. We believe that these results will facilitate the diagnosis, prevention, and control of PCV2 and PCV3 in China.
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Cui et al. (2023) conducted a cross-sectional in PCV2 and PCV3 infection (n=1,201). PCV2 and PCV3 was evaluated on Infection rate of PCV2 and PCV3. Among 1,201 swine samples from China, the infection rates of PCV2 and PCV3 were 72.1% and 26.3%, respectively, with a coinfection rate of 18.6% and PCV2d as the dominant genotype.
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