Key result
PCV2 was detected in 356 of 685 samples from unthrifty pigs in Southeast China, with PCV2d identified as the predominant circulating strain and PCV2e reported for the first time in China.
Cross-Sectional (n=685)
Yes
PCV2d is the predominant circulating strain in swineherds in Fujian, China, and PCV2e is reported for the first time in China, highlighting continuous viral evolution and genetic diversity.
Porcine circovirus 2 (PCV2) has been prevalent in swine herds in China since 2002, causing severe economic loss to the pig industry. The number of live pigs in southeast China is > 20 million. Since information on the genetic variation of PCV2 in the Fujian province is limited, the objective of the present work was to investigate the epidemiological and evolutionary characteristics of PCV2 in southeast China from 2013 to 2017. Of the 685 samples collected from 90 different swine herds from 2013 to 2017, 356 samples from 84 different swine herds were positive for PCV2. PCV2a, PCV2b, PCV2d, and PCV2e co-existed in the Fujian province, with PCV2d being the predominant circulating strain in swineherds and PCV2e being reported for the first time in China. Strikingly, PCV2-FJ-water DNA comes from contaminated river water and not infected animals. Sequence comparison among all isolates indicated that 95 isolates shared approximately 78.7%-100% nucleotide identity and 74.5%-100% amino acid identity for open reading frame 2 (ORF2). Amino acid alignment showed that the Cap protein of PCV2e differed markedly from those of PCV2a, PCV2b, PCV2c, and PCV2d. These results indicated that various PCV2 genotypes exist in China, and that PCV2 is continuously evolving, leading to rapid emergence of new variant stains.
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Liu et al. (2018) conducted a cross-sectional in Porcine circovirus 2 (PCV2) infection (n=685). PCV2 was evaluated on PCV2 positivity rate and genotype distribution. PCV2 was detected in 356 of 685 samples from unthrifty pigs in Southeast China, with PCV2d identified as the predominant circulating strain and PCV2e reported for the first time in China.
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