Key result
Genetic analysis reveals PCV2d has replaced PCV2b as the predominant porcine virus since 2014.
Why the study?
Porcine circovirus 2-associated disease is an economically important swine disease, and this study aimed to characterize and determine the genetic diversity of PCV2 in Guangxi, China.
Observational (n=95)
The study demonstrates the genetic diversity of PCV2 in southern China, highlighting the emergence of PCV2d as the dominant sub-genotype since 2014.
PCV2 strains in Guangxi show high genetic diversity; leaves open whether current vaccines suffice for regional swine control.
BACKGROUND: Porcine circovirus 2-associated disease (PCVAD) is acknowledged as one of the most economically important diseases for the swine industry worldwide. The aim of this study was to characterize and determine the genetic diversity of PCV2 in the porcine population of Guangxi, China. METHODS: The full length genome and open reading frame 2 (ORF2) of 95 PCV2 strains collected from the tissues and sera of pigs that had either died as a result of PCVAD or did not exhibit disease symptoms were analyzed. RESULTS: The results of multiple sequence alignments showed that there is considerable diversity among the PCV2 ORF2 sequences. Phylogenetic analyses based on the complete genome showed that current PCV2 strains in this study could be divided into PCV2a (1/95), PCV2b (39/95), PCV2d (43/95), PCV2e (10/95) and PCV2h (2/95). Among the 5 sub-genotypes, PCV2b was dominant in the porcine population from 2002 to 2008. The newly identified sub-genotype, PCV2d, was seen from 2003 and has increased every year. PCV2b and PCV2d formed two predominant genetic groups circulating in southern China between 2009 and 2013 and the sub-genotype PCV2d has become the dominant virus in China since 2014. CONCLUSIONS: This study reveals the complex genetic diversity of PCV2 and improves our understanding regarding the epidemiological trends of PCV2 sub-genotypes in China.
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Yao et al. (2019) conducted an observational in Porcine circovirus 2 (PCV2) infection (n=95). PCV2 sub-genotypes was evaluated on Prevalence and genetic diversity of PCV2 sub-genotypes. Genetic analysis of 95 PCV2 strains from pigs in Guangxi, China revealed that PCV2b was dominant from 2002 to 2008, but the PCV2d sub-genotype has become the predominant virus since 2014.
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