What question did this study set out to answer?

To quantify the increased risk of delayed union, non-union, and prolonged time to union in smokers compared to non-smokers across fractures, osteotomies, and arthrodeses.

November 1, 2016BMJ OpenOpen Access

Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis? A systematic review with meta-analysis

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Authors

RPRichard G. PearsonQueen's Medical Centre RCR ClémentCentre National de la Recherche Scientifique KEK L EdwardsUniversity of Nottingham

Discussion

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Implication

Systematic review and meta-analysis finds double the risk of delayed or non-union in adult smokers undergoing orthopaedic procedures, highlighting the need for perioperative smoking cessation.

Key Points

To quantify the increased risk of delayed union, non-union, and prolonged time to union in smokers compared to non-smokers across fractures, osteotomies, and arthrodeses.
Systematic review and meta-analysis of observational cohort studies indexed in MEDLINE, EMBASE, AMED, and Web of Science Core Collection from 1966 to 2015.
Identified 3,013 articles and included 40 studies evaluating adult smokers versus non-smokers across 7,516 orthopaedic procedures.
Smokers had more than double the risk of experiencing delayed union or non-union compared to non-smokers across 7,516 procedures (RR 2.2, 95% CI 1.9 to 2.6), with all subgroup risks remaining elevated (RR ≥ 1.6).
In procedures where bone union successfully occurred (923 procedures), smokers experienced an average delay in time to union of 27.7 days (95% CI 14.2 to 41.3 days).

Cite This Study

Pearson et al. (2016) studied this question.

synapsesocial.com/papers/6a881ecc6304c7fd8e4df384 https://doi.org/10.1136/bmjopen-2015-010303

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Implication

Systematic review and meta-analysis finds double the risk of delayed or non-union in adult smokers undergoing orthopaedic procedures, highlighting the need for perioperative smoking cessation.

Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis? A systematic review with meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis? A systematic review with meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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