What question did this study set out to answer?

To determine the genetic linkage relationships between the HL-A–PGM3 complex, 19 marker loci, and cystic fibrosis.

May 1, 1975Annals of Human Genetics

Data on the HL‐A linkage group

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Authors

LLL.U. LammSt Thomas' Hospital ITINGE‐LIS ThorsenAarhus University Hospital GPGitte PetersenStockholm University

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Implication

Family linkage study reveals weak evidence linking cystic fibrosis to PGM3 across 229 families, highlighting refined boundaries for the HLA linkage group.

Key Points

To determine the genetic linkage relationships between the HL-A–PGM3 complex, 19 marker loci, and cystic fibrosis.
Analyzed lod scores across 229 families to assess genetic linkage.
Evaluated linkage relations between the HL-A-PGM3 region, cystic fibrosis, and 19 genetic marker loci.
Excluded adenosine deaminase (ADA) from the HL-A linkage group, with weak support observed for the inclusion of the P locus.
Found weak evidence for genetic linkage between cystic fibrosis and PGM3, but no linkage between cystic fibrosis and HL-A.
Identified no additional suggestive linkages among the evaluated marker loci.

Cite This Study

Lamm et al. (1975) studied this question.

synapsesocial.com/papers/6a881ef48dfe8b7ec5a539bf https://doi.org/10.1111/j.1469-1809.1975.tb00628.x

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Implication

Family linkage study reveals weak evidence linking cystic fibrosis to PGM3 across 229 families, highlighting refined boundaries for the HLA linkage group.

Data on the HL‐A linkage group

Discussion

Member takes

Implication

Key Points

Cite This Study

Data on the HL‐A linkage group

Discussion

Member takes

Implication

Key Points

Cite This Study

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