Key result
Cardiac circulation duration measured by coronary computed tomography angiography was significantly shorter in patients with flat T waves (9.50 seconds) compared to normal subjects (10.57 seconds).
Why the study?
The study was conducted to evaluate coronary circulation perfusion, related factors, and peak filling time differences between the aortic sinus and coronary sinus using CCTA.
Does CCTA-derived cardiac circulation duration correlate with coronary artery stenosis and clinical symptoms in outpatients with angina pectoris?
Observational (n=61)
Blinded assessors
No
Does CCTA-derived cardiac circulation duration correlate with coronary artery stenosis and clinical symptoms in outpatients with angina pectoris?
Absolute Event Rate: 9.5% vs 10.57%
p-value: p=0.021
CCTA can noninvasively assess cardiac microcirculation at rest by measuring the difference in peak filling times between the aortic and coronary sinuses, which correlates with coronary stenosis and ECG abnormalities.
Shorter CCTA circulation time associated with flat T waves and proximal stenosis; hypothesis-generating for microcirculation assessment in angina outpatients.
To evaluate the perfusion of coronary circulation and its related factors and the difference in the peak filling times in aortic sinus and coronary sinus by coronary computed tomography angiography (CCTA).From January 1 to August 1, 2018, 61 outpatients with angina pectoris were recruited, completed a questionnaire about risk factors and underwent CCTA, which was also used to assess the stenosis of different coronary artery segments.The duration of circulation was 9.50 ± 2.43 seconds in patients with flat T wave, which was shorter than the duration in normal subjects (P = .021). However, other cardiovascular risk factors showed no effect on the duration of circulation. In addition, the duration of circulation was closely related to the peak filling time of coronary sinus [r(s) = 0.681]. We further divided the circulation time difference (delta) values into 3 levels (<6, 6-12, and ≥12 seconds).It showed that the circulation duration (Y) was associated with:Therefore, the cardiac circulation duration was negatively related to the degree of stenosis in the 1 diagonal and proximal LCA.It compensates for the inability of CCTA to assess circulation at rest simply by determining the peak filling time in the aortic sinus and the coronary sinus. Moderate cardiac microcirculation duration was related to a low incidence of clinical symptoms and electrocardiogram disorders, which was determined mainly by the diagonal and left circumflex branch 1 of LCA.
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Chen et al. (2020) conducted an observational in Angina pectoris (n=61). Abnormal electrocardiogram (flat T wave) vs. Normal electrocardiogram was evaluated on Cardiac circulation duration (p=0.021). Cardiac circulation duration measured by coronary computed tomography angiography was significantly shorter in patients with flat T waves (9.50 seconds) compared to normal subjects (10.57 seconds).
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