Self-aggregation of reverse bis peptide conjugate derived from the unstructured region of the prion proteinElectronic supplementary information (ESI) available: experimental section. See http://www.rsc.org/suppdata/cc/b3/b316793c/

A novel bis scaffold containing a pentapeptide PHGGG, derived from the prion octarepeat, forms fibrils of nanometric dimensions, thus indicating that certain segments in the unstructured region of the prion protein may facilitate an initial fibrillation event.