Key result
The recently cloned (pro)renin receptor induces angiotensin-independent effects, suggesting renin and prorenin act as agonists and highlighting the potential for (pro)renin receptor blockers.
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The discovery of a (pro)renin receptor with angiotensin-independent effects suggests a potential novel therapeutic target for cardiovascular disease.
It is generally assumed that the beneficial effects of renin-angiotensin system blockers in cardiovascular disease are due to blockade of the generation or action of angiotensin at tissue sites. Such generation depends on the uptake of renin and/or its inactive precursor prorenin from the circulation. Recently, a (pro)renin receptor has been cloned that might perform this task. Unexpectedly, this receptor also induced angiotensin-independent effects, suggesting that renin and/or prorenin may act as agonists for this receptor. Ultimately, this could lead to the development of (pro)renin receptor blockers (i.e., drugs that not only prevent tissue angiotensin generation but also inhibit renin- or prorenin-induced effects).
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Nguyen et al. (2006) conducted a review in Cardiovascular disease. (pro)renin receptor blockers was evaluated. The recently cloned (pro)renin receptor induces angiotensin-independent effects, suggesting renin and prorenin act as agonists and highlighting the potential for (pro)renin receptor blockers.
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