What does this research mean for the field?

The (pro)renin receptor system exerts both angiotensin-independent intracellular signaling effects and angiotensin-dependent catalytic effects, which may drive pathological remodeling and fibrosis, raising concerns about the consequences of elevated renin and prorenin levels induced by renin inhibitor therapy. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 31, 2008Experimental PhysiologyOpen Access

Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents

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Population

in vitro studies and experimental models in rodents

Design

Review

Authors

GNGeneviève NguyenInstitut National Polytechnique de Toulouse ADA.H. Jan DanserVascular Medicine

Discussion

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Implication

Supports (P)RR blockade exploration in experimental diabetic complications; leaves open clinical translation and safety.

Structured PICO

Population

in vitro studies and experimental models in rodents

Intervention

(pro)renin receptor blockers and renin inhibitors

This review highlights the dual functions of the (pro)renin receptor and the potential therapeutic value of its blockade in preventing fibrosis and nephropathy, while raising theoretical concerns about increased (P)RR activation with clinical renin inhibitors.

Cite This Study

Nguyen et al. (2008) studied this question.

synapsesocial.com/papers/6a1d7f75102421609405722f https://doi.org/10.1113/expphysiol.2007.040030

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Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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