Key result
This review summarizes the binding kinetics and signaling of the (pro)renin receptor, as well as its interaction with prorenin and the renin inhibitor aliskiren.
This review summarizes the binding kinetics, signaling pathways, and interactions of prorenin and its receptor with the renin inhibitor aliskiren.
Does not support changes in aliskiren use; leaves open clinical relevance of (pro)renin receptor targeting.
Introduction Recent studies suggests that prorenin, the ‘inactive’ precursor of renin, may have a function of its own. This relates to the discovery of the (pro)renin receptor [(P)RR], which binds and activates prorenin. In addition, prorenin may act as an agonist for this receptor, directly stimulating signalling pathways in an angiotensin (Ang)-independent manner. This review summarises the findings from three publications on prorenin and its receptor, focusing, respectively, on the binding kinetics and signalling of the (P)RR, as well as on the possibility of an interaction between prorenin, the (P)RR and the renin inhibitor aliskiren.
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Batenburg et al. (2008) reported a review. Prorenin, (pro)renin receptor, and aliskiren was evaluated. This review summarizes the binding kinetics and signaling of the (pro)renin receptor, as well as its interaction with prorenin and the renin inhibitor aliskiren.
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