Glutamate Dehydrogenase: Amino-Acid Sequence of the Bovine Enzyme and Comparison with That from Chicken Liver

Further investigation of the amino-acid sequence of bovine glutamate dehydrogenase (EC 1.4.1.3) has led to the correction of an earlier tentative sequence. The presently known sequence contains 500 residues in the subunit single peptide chain. The sequence of the homologous enzyme from chicken liver indicates that it contains 503 residues. Of the presently established 485 residues in the chicken dehydrogenase, only 26 residues differ from those in the bovine enzyme. The chicken dehydrogenase also differs in having an additional three residues at the amino terminus. The amino-terminal residue of the chicken enzyme was found to be cysteic acid.