Key result
Adipocyte lipoprotein lipase knockout affected brown but not white fat composition, demonstrating that lipoprotein lipase distribution and adipose metabolism affect adipogenesis.
Population
Adipose-specific LpL knock-out mice, whole body LpL knock-out mice rescued with muscle LpL expression, and…
Comparison
Adipose-specific lipoprotein lipase knock-out… vs Wild type (WT) mice
Design
Preclinical
Follow-up
up to 16 weeks of age
Authors
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LpL distribution may modulate brown fat adipogenesis in mice; leaves open relevance to human lipoprotein clearance or obesity.
Adipocyte lipoprotein lipase in brown adipose tissue modulates plasma lipoprotein clearance, and loss of adipose LpL reduces fat accumulation only if accompanied by greater LpL activity in muscle.
García‐Arcos et al. (2013) studied Lipoprotein Lipase Deficiency. Adipose-specific Lipoprotein Lipase (LpL) knockout vs. Wild type (WT) mice was evaluated on Brown and white fat composition and plasma triglyceride levels. Adipocyte lipoprotein lipase knockout affected brown but not white fat composition, demonstrating that lipoprotein lipase distribution and adipose metabolism affect adipogenesis.
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