September 1, 1998Journal of Cell Science
Sensory nerves affect the recruitment and differentiation of rat periovarian brown adipocytes during cold acclimation
Population
Rats (periovarian adipose tissue)
Comparison
Systemic capsaicin administration combined with… vs Rats without capsaicin administration
Design
Preclinical
Follow-up
14 days
Authors
Discussion
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Member takes
Implication
Capsaicin attenuates cold-induced brown adipocyte recruitment in rats; hypothesis-generating for sensory neuropeptide roles in thermogenesis, no clinical implications yet.
Structured PICO
P
Population
Rats (periovarian adipose tissue)
I
Intervention
Systemic capsaicin administration (desensitization) combined with cold acclimation (4 degrees C for 14 days) or room temperature (20 degrees C)
C
Comparator
Rats without capsaicin administration
O
Outcome
Brown adipocyte density and expression of substance P and calcitonin gene-related peptidesurrogate
Sensory neuropeptide-containing nerves play a role in the recruitment and differentiation of brown adipocytes during cold acclimation in rats.
Cite This Study
Giordano et al. (1998) studied this question.