Key result
An intensive weight-loss lifestyle intervention combining an energy-reduced Mediterranean diet and physical activity significantly reduced the 1-year decline in eGFR by 0.58 ml/min/1.73m2 compared to an ad libitum Mediterranean diet.
Why the study?
Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including a Mediterranean diet on renal function were lacking.
Does an intensive weight-loss lifestyle intervention with an energy-reduced Mediterranean diet improve 1-year change in eGFR in overweight/obese adults with metabolic syndrome?
Population
6719 overweight/obese adults aged 55-75 years with metabolic syndrome
Comparison
Intensive weight-loss lifestyle intervention with energy-reduced MedDiet vs usual-care energy-unrestricted MedDiet advice
Design
Multicenter randomized controlled trial
Follow-up
1 year
Authors
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Supports intensive Mediterranean diet intervention to slow eGFR decline in metabolic syndrome; extends RCT evidence for lifestyle renal protection.
RCT (n=6,719)
Open-label
1:1 computer-generated random number internet-based system, stratified by sex, age, and center
Yes
Does an intensive weight-loss lifestyle intervention with an energy-reduced Mediterranean diet improve 1-year change in eGFR in overweight/obese adults with metabolic syndrome?
Mean Difference: 0.58 (95% CI 0.15–1.02)
Absolute Event Rate: -0.66% vs -1.25%
p-value: p=0.008
An intensive weight-loss lifestyle intervention featuring an energy-reduced Mediterranean diet and physical activity significantly preserves renal function and reduces the incidence of chronic kidney disease in overweight and obese adults with metabolic syndrome.
Díaz‐López et al. (2020) conducted an RCT in Metabolic syndrome and overweight/obesity (n=6,719). Intensive weight-loss lifestyle intervention (energy-reduced Mediterranean diet, physical activity promotion, and behavioral support) vs. Usual-care advice to adhere to an energy-unrestricted Mediterranean diet was evaluated on 1-year change in estimated glomerular filtration rate (eGFR) (MD 0.58, 95% CI 0.15 to 1.02, p=0.008). An intensive weight-loss lifestyle intervention combining an energy-reduced Mediterranean diet and physical activity significantly reduced the 1-year decline in eGFR by 0.58 ml/min/1.73m2 compared to an ad libitum Mediterranean diet.
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