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Glucocorticoids are known to bind to liver cytosol proteins and alter nuclear RNA synthesis. Nuclear proteins are believed to assist in the regulation of nuclear RNA synthesis. The work reported here tested the possibilities that one of the very early effects of corticosterone treatment in rats consists of altered phosphorylation of nuclear proteins and that cytosol steroid-receptor complexes are necessary for altered phosphorylation of nuclear proteins.
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Bottoms et al. (1973) studied this question.
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