What question did this study set out to answer?

To determine whether a cholesteryl oligo-d-arginine carrier stabilizes VEGF-targeting siRNA and enhances its antitumor efficacy in colon adenocarcinoma.

June 13, 2006Molecular TherapyOpen Access

Cholesteryl Oligoarginine Delivering Vascular Endothelial Growth Factor siRNA Effectively Inhibits Tumor Growth in Colon Adenocarcinoma

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To determine whether a cholesteryl oligo-d-arginine carrier stabilizes VEGF-targeting siRNA and enhances its antitumor efficacy in colon adenocarcinoma.
Formed noncovalent complexes between synthetic siRNA (VEGF-targeting or scrambled control) and the cholesteryl oligo-d-arginine (Chol-R9) peptide vector to evaluate in vitro delivery.
Administered complexed VEGF-targeting siRNA locally to evaluate tumor regression in a subcutaneous colon adenocarcinoma mouse model.
Chol-R9 noncovalently complexed with synthetic siRNA achieved efficient intracellular delivery into cells in vitro.
Local in vivo administration of Chol-R9-complexed VEGF siRNA induced significant tumor regression, whereas scrambled siRNA complexes showed no antitumor effect.

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Implication

Preclinical study demonstrates tumor regression from Chol-R9-delivered VEGF siRNA in a colon adenocarcinoma model, indicating a potential local gene therapy approach.

Cite This Study

Kim et al. (2006) studied this question.

synapsesocial.com/papers/6a88247a6304c7fd8e4df4d7 https://doi.org/10.1016/j.ymthe.2006.03.022

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Implication

Preclinical study demonstrates tumor regression from Chol-R9-delivered VEGF siRNA in a colon adenocarcinoma model, indicating a potential local gene therapy approach.

Cholesteryl Oligoarginine Delivering Vascular Endothelial Growth Factor siRNA Effectively Inhibits Tumor Growth in Colon Adenocarcinoma

Key Points

Discussion

Implication

Cite This Study

Cholesteryl Oligoarginine Delivering Vascular Endothelial Growth Factor siRNA Effectively Inhibits Tumor Growth in Colon Adenocarcinoma

Key Points

Discussion

Implication

Cite This Study

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